• However recent studies revealed that the function of

  2019-08-13

  

  However, recent studies revealed that the function of Crm1 might not only limit to nucleocytoplasmic transport, but also be involved in regulation of centrosome duplication. As the major microtubule organizing centers in animal cells, centrosomes play a significant role in cell cycle, spindle format

• In conclusion the present study demonstrates

  2019-08-13

  

  In conclusion, the present study demonstrates that E2\'s antiapoptotic effects are significantly reduced by coadministration of progestogens. The combination of E2 and progestogens resulted in diverging effects on the expressions of ERs and PRs, which induced different effects on the cell growth of

• CYP A and CYP D are among the main drug

  2019-08-13

  

  CYP3A4/5 and CYP2D6 are among the main drug-metabolizing enzymes in humans that are responsible for the metabolism of more than 50% of marketed drugs [19], [21]. Drugs metabolized by CYPs are prone to drug–drug interactions, thereby modifying their response [18], [32]. Metabolic inhibition is also i

• Oxysterols modulate the immune responses and as such could

  2019-08-13

  

  Oxysterols modulate the immune responses and as such could be effectors of the tumor environment: 25-OHC impairs IgA production in B-lymphocytes [26] and induces the secretion of the proinflammatory and angiogenic cytokine IL-8 [27], [28]. Of note, oxysterols (in particular 7α,25-OHC) are potent che

• br The classical ubiquitination pathway Ubiquitination is

  2019-08-13

  

  The classical ubiquitination pathway Ubiquitination is an enzymatic process that involves the addition of an ubiquitin protein to a substrate that usually becomes inactivated followed by degradation in the proteasome; however, several other functions have also been described. For the discovery of

• Abdominal aortic aneurysm AAA is considered

  2019-08-13

  

  Abdominal aortic aneurysm (AAA) is considered a major health concern and is associated with extremely high rates of mortality in case of aortic rupture. The main pathophysiologic mechanisms leading to aortic dilation include the degradation of the extracellular matrix (ECM) components, such as colla

• GDC-0199 While previously reported optimizations on compound

  2019-08-13

  

  While previously reported optimizations on GDC-0199 focused on the phenyl ring A () and substituents on isoxazole ring, other alternatives to replace isoxazole ring were never explored. Herein, we propose to replace the isoxazole with its bioisosteric substituted phenyl ring B () to explore new chem

• The efficacy of A in the ob

  2019-08-13

  

  The efficacy of A-922500 in the ob/ob mouse model is of particular interest for two reasons. One of the most striking features of the DGAT-1 deficient mouse phenotype is the resistance to diet-induced obesity (Smith et al., 2000). However, TAK-875 of DGAT-1 in leptin deficient ob/ob mice failed to

• br Experimental procedures br Introduction Protein kinases r

  2019-08-13

  

  Experimental procedures Introduction Protein kinases represent one of the largest enzyme Caffeine calculator in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase activity

• br Results br Discussion Thus the biochemical and structural

  2019-08-13

  

  Results Discussion Thus, the biochemical and structural studies of six Maf proteins from different organisms have revealed two subfamilies of new enzymes with the metal-dependent nucleoside triphosphate pyrophosphatase activity against both canonical and noncanonical pyrimidine nucleotides (Yh

• br Materials and methods br Results br Discussion Although n

  2019-08-13

  

  Materials and methods Results Discussion Although no increase in DAPK activity was detected at early time points associated with neuronal apoptosis, it is possible that the spread of apoptosis through the MnTBAP Chloride in following HI is not synchronized enough to yield a large, consiste

• Recent studies have shown arsenic could cause autophagic cel

  2019-08-13

  

  Recent studies have shown arsenic could cause autophagic cell death in malignant cells, including leukemia and malignant glioma Wortmannin [16], [17]. However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related proteins.

• Pathological changes in animal are

  2019-08-13

  

  Pathological changes in animal are powerful indicators of the exposure to environmental stressors. The liver serves as an appropriate organ for the study of pollutant effects because of its high capacity to accumulate pollutant and its susceptibility to histopathological damage by pollutants (Padmin

• For the SAR optimization of the right hand

  2019-08-12

  

  For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic However moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy linker was introduced by condensatio

• Industrial fermentation aims to produce

  2019-08-12

  

  Industrial fermentation aims to produce valuable products from cheap feedstocks by utilizing diverse microbial functions through aerobic or anaerobic fermentation [[8], [9], [10]]. During anaerobic fermentation, the reducing power is mostly directed to product synthesis rather than being oxidized, r

15004 records 997/1001 page Previous Next First page 上5页 9969979989991000 下5页 Last page