• Cells expressing the CDK S

  2020-12-21

  

  Cells expressing the CDK5 S47D mutant exhibit impaired migration and enhanced proliferation: Finally, we wished to determine the functional significance of this phosphoevent. Multiple studies have implicated active CDK5 in promotion of cell migration [9,16,[21], [22], [23], [24]] and in one study th

• br Results br Discussion Unraveling the molecular

  2020-12-21

  

  Results Discussion Unraveling the molecular details of nucleoporin-karyopherin interactions, which have to be strong enough to promote transport but sufficiently weak to avoid stalling of transport complexes within the pore, is key to our understanding of the mechanisms of nucleocytoplasmic tr

• Unexpectedly CRF receptor agonist and antagonist

  2020-12-21

  

  Unexpectedly, CRF2 receptor agonist and antagonist evoked similar effects in the fall in tail skin temperature caused by restraint. However, Ucn3 reduced basal values of tail skin temperature, thus indicating that some degree of basal vasoconstriction caused by BNST treatment with Ucn3 may have cont

• br Results On the th

  2020-12-21

  

  Results On the 8th day, the horizontal (Fig. 1) and vertical locomotor activity (Fig. 2) and the dorsal (Fig. 3) and Aloperine striatal dopamine release (Fig. 4) increased significantly in nicotine-treated rats, compared with the saline-treated rats. Tukey post-hoc test revealed the following p

• We and others have previously found

  2020-12-21

  

  We and others have previously found that supplementation of old rats with ALCAR remediates the age-related decay in mitochondrial bioenergetics in liver (Hagen et al., 1998a, Hagen et al., 1998b), heart (Paradies et al., 1994, Paradies et al., 1999), muscle (Pesce et al., 2010) and Loratadine (Liu e

• Application of the CPH model relies on the assumption

  2020-12-21

  

  Application of the CPH model relies on the assumption that the hazard ratio of two observations is constant over time [2]. This enables us to infer the rate of risk of the treatment. For example, in the study of patients with pulmonary arterial hypertension (PAH) [5], the hazard ratio of a group of

• SEA0400 synthesis The proposed FDIR technique is presented

  2020-12-21

  

  The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the SEA0400 synthesis environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estima

• On the other hand the properties of collagen

  2020-12-21

  

  On the other hand, the properties of collagen materials could be efficiently improved by proper chemical modification. The crosslinking agents for collagen generally involve aldehydes (e.g., glutaraldehyde (GA), isocyanates (e.g., hexamethylene diisocyanate (HMDI), photoreactive agents, polyepoxy co

• We did not observe inhibition of

  2020-12-21

  

  We did not observe inhibition of vCPH by any of the TCA cycle intermediates (apart from the metal chelators citrate and isocitrate), nor by the factor inhibiting HIF (FIH; a 2OG-dependent asparaginyl hydroxylase) inhibitor N-oxalyl d-phenylalanine (NOF) or the γ-butyrobetaine dioxygenase inhibitor m

• The reference standards methyl difluoro dioxolo

  2020-12-21

  

  The reference standards methyl 3-((2,2-difluoro-5-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-]imidazol-6-yl)carbamoyl)benzoate () and -(2,2-difluoro-5-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-]imidazol-6-yl)-3-methoxybenzamide (), and their corresponding desmethylated precursors 3-((2,2-difluoro-5-[1,3]dioxolo[4′,5′:

• To date little is known about mode of action or

  2020-12-21

  

  To date, little is known about mode of action or the underlying genetic basis of DEET repellency for human-biting ticks. To begin to unveil these mechanisms, we carried out behavioral assays to confirm the effectiveness of DEET as a deterrent for D. variabilis. RNA sequencing was then used to build

• In rodent models the loss of

  2020-12-21

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an Cy5 amine (non-sulfonated) australia receptor beta agonist restores its protective effect, but is abolished with the introduction of

• A variety of epidemiological and clinical studies suggest

  2020-12-21

  

  A variety of epidemiological and clinical studies suggest that light alcohol consumption may exert a favorable effects on BP levels but chronic heavy alcohol consumtion causes sustained BP elevation [16], [17]. The hypertensive effect of heavy drinking occurs with all forms of alcohol (i.e. beer win

• e mycin australia The interaction of EPAC with Rim

  2020-12-18

  

  The interaction of EPAC2 with Rim1 has an important role in regulating neurotransmitter release. In addition, a recent EPAC2 knockout mice model study provides evidence that EPAC2 promotes transmitter release by maintaining the readily releasable pool (RRP) at mossy fiber (MF) synapses in the hippo

• ISRIB Using the juxtarenal PPE the induction of juxta

  2020-12-18

  

  Using the juxtarenal PPE, the induction of juxta- and suprarenal aneurysms is described herein (Fig. 3A). The infra-/suprarenal part of the ISRIB can now be investigated separately, taking into account different embryological backgrounds and varying reactivity to differing stimuli (reviewed by Linds

15128 records 753/1009 page Previous Next First page 上5页 751752753754755 下5页 Last page