• A major open question in the field of

  2021-03-01

  

  A major open question in the field of lipid mediators is the molecular nature of the PLA2 enzyme involved in the release of DHA and related omega-3 fatty acids from phospholipids as a first committed step for the generation of SPMs. Although by analogy with AA it is often assumed that cPLA2α may ser

• Repulsive interactions towards undesirable substrates are

  2021-03-01

  

  Repulsive interactions towards undesirable substrates are arguably a very efficient means to implement specificity [8]. In particular, it could be assumed that discrimination against a substrate that is larger than the cognate substrate may be achieved easily by restricting the active site and explo

• The synthesis of the required substrates is shown

  2021-03-01

  

  The synthesis of the required substrates is shown in (see for experimental details). Treatment of heterocycle with DOI hydrochloride under basic conditions afforded a mixture of the mono-substituted product (22%) and the di-substituted compound (38%) which were separated by column chromatogra

• Early VL diagnosis makes it

  2021-03-01

  

  Early VL diagnosis makes it possible to formulate a quicker and more effective treatment against the disease, which could increase the possibility of a cure for the patients, as well as reduce the toxicity of the drugs (Coelho et al., 2009); however, conventional and molecular parasitological method

• It has previously been established

  2021-03-01

  

  It has previously been established that DDRs play an important role in collagen regulation in at least two distinct ways: (1) activation of DDRs by collagen results in up-regulation of the matrix metalloproteinases, which results in cleavage and degradation of the ECM20., 21., [22] and (2) 77 austra

• Environmental cues such as microbial dietary and neuronal si

  2021-03-01

  

  Environmental cues, such as microbial, dietary, and neuronal signals, regulate the differentiation and function of ILC3s. However, the identities of any additional cues and the receptors that detect them remain unknown. An important class of proteins enabling cells to sense extracellular cues are G-

• Both meiotic COs and NCOs require DNA

  2021-02-27

  

  Both meiotic COs and NCOs require DNA synthesis, current data from sequencing also suggest that COs require more DNA synthesis than NCO 63., 64., 65.. However, analysis of the role of DNA synthesis in NCOs remains relatively uncharacterized. Emerging evidence points to a role for either Polδ or Polε

• On the other hand the death

  2021-02-27

  

  On the other hand, the death domain is a conserved stretch of around 80AA which is commonly found in death receptor proteins, it play a major role in the interaction between other proteins. Also as a platform for the death-inducing signaling complex (DISC) formation (Chaigne-Delalande et al., 2008).

• br Conclusion br Conflict of interest br Acknowledgments The

  2021-02-27

  

  Conclusion Conflict of interest Acknowledgments The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding the work through the research group project No. RGP-120. Introduction Methods Results Conclusions Introduction Pat

• Phylogenetic analysis indicates that in poikilothermic verte

  2021-02-27

  

  Phylogenetic analysis indicates that in poikilothermic vertebrates CXCR3a and CXCR3b have evolved independently from a common gene possibly after the 2nd round whole genome duplication but before the split of bony fish and tetrapods (Fig. 1 and Supplementary file 3). Owing to the extra round of whol

• Introduction Globally lung cancer has the highest morbidity

  2021-02-27

  

  Introduction Globally, lung cancer has the highest morbidity and mortality rates of all types of cancer, with 1.5 million patients newly diagnosed annually [1]. Approximately 85% of lung cancer cases are non-small cell lung cancer (NSCLC) [2]. The first-line treatment for NSCLC is surgical resectio

• Endothelial dysfunction has been associated with most

  2021-02-27

  

  Endothelial dysfunction has been associated with most of the established cardiovascular risk factors, such as hypercholesterolemia, hypertension, smoking, diabetes mellitus, a positive history of premature CAD and elevated hif pathway homocysteine 4, 26, 27. Endothelial dysfunction is present in th

• br Introduction Receptor tyrosine kinases

  2021-02-27

  

  Introduction Receptor tyrosine kinases (RTKs) are critically involved in the development and progression of human cancers and are therefore useful targets for anti-cancer therapies [1]. The Eph receptors represent the largest subfamily of receptor protein kinases and interact with ligands called

• Increased leukocyte trafficking and infiltration of the vasc

  2021-02-27

  

  Increased leukocyte trafficking and infiltration of the vascular wall are thought to provide a key stimulus for SMC activation and subsequent neointima formation in response to vascular injury [19], [20]. The essential trigger regulating the accumulation of leukocytes in the vessel wall is the upreg

• br Introduction Epithelial mesenchymal transition EMT is

  2021-02-27

  

  Introduction Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial Sulfo-NHS-Biotin lose cell polarity and cell-cell adhesion, and gain mesenchymal features with an increase of migratory and invasive properties [1]. EMT is essential for mesoderm formation during embr

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