• Waldeck Weiermair et al demonstrated that in endothelial cel

  2021-10-20

  

  Waldeck-Weiermair et al. (2008) demonstrated that in endothelial cells, the activation of GPR55 by application of 10µM anandamide resulted in a marked increase of ERK1/2 phosphorylation that was evident 2min following drug activation and was sustained for up to 3h. Another example comes from our unp

• NCT-502 receptor Recent studies on detailed biochemical and

  2021-10-20

  

  Recent studies on detailed biochemical and structural characterization of plant GSNOR NCT-502 receptor confirmed their similarities to mammalian homologues [16], [17], [18], [19]. Compared to human GSNOR, plant GSNORs exhibit differences in the composition of the anion-binding pocket, which negativ

• Another important question is what ligand s bind

  2021-10-20

  

  Another important question is what ligand(s) bind to GPR84 in vivo? Previous studies have identified medium-chain FFAs of 9 to 14 carbons in length and two other organic molecules (6-n-octylaminouracil and 3,3′-diindolylmethane) as agonists of GPR84 in vitro (Wang et al., 2006, Suzuki et al., 2013).

• br Results br Discussion Cell contact

  2021-10-20

  

  Results Discussion Cell-contact-mediated spread of HIV-1 has been estimated to be at least an order of magnitude more efficient compared to passive dissemination of particles through the extracellular milieu. Thus, this form of viral transmission can have significant effects on the pathogenesi

• br Conclusion br Conflict of interest statement

  2021-10-20

  

  Conclusion Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as Introduction Over the past decade, more than a hundred new biopharmaceutical products have been approved and market

• br Introduction Glycoproteins represent a staggeringly small

  2021-10-20

  

  Introduction Glycoproteins represent a staggeringly small fraction of proteins analyzed by high-resolution techniques despite high concentrations at the cell surface and critical roles in many human diseases. Though one-half or more of all human proteins are predicted to contain a carbohydrate ch

• br Conclusions br Conflicts of Interest br Acknowledgments T

  2021-10-19

  

  Conclusions Conflicts of Interest Acknowledgments The Section of Endocrinology and Investigative Medicine is funded by grants from the Medical Research Council (MRC), Biotechnology & Biological Sciences Research Council (BBSRC), National Institute for Health Research (NIHR), an Integrative

• The current study aimed to understand the

  2021-10-19

  

  The current study aimed to understand the roles and the underlying mechanisms of XIST in LSCC, by focusing on the regulation by miR-124-3p, which was previously identified as a target of XIST [12]. We found that the XIST expression is positively correlated with the stages of LSCC in patients. Knockd

• PRT-060318 mg To identify genes with significant expression

  2021-10-19

  

  To identify genes with significant PRT-060318 mg differences, we performed differential gene expression analysis between the two individuals with TRRAP variants (combined as biological replicates) and two unaffected controls. Gene ontology (GO) enrichment analysis of these genes with the GOrilla we

• In recent large clinical studies AIM HIGH and

  2021-10-19

  

  In recent large clinical studies, AIM-HIGH and HPS2-THRIVE, the additional treatment of nicotinic mct2 pathway to statin-based LDL-C lowering therapy did not decrease the major vascular events on the patients who had atherosclerotic vascular diseases [43,44]. In the AIM-HIGH study, the secondary an

• The activation of the ERK pathway participates in the

  2021-10-19

  

  The activation of the ERK pathway participates in the transmission of pain signaling by sensitizing primary afferents (Ji et al., 2009, Lai et al., 2011). Thus, the blockade of ERK activation in the primary sensory AGK7 mg can reduce the mechanical hypersensitivity and the thermal hypersensitivity

• In humans the effect of GnRH and hCG on

  2021-10-19

  

  In humans, the effect of GnRH and hCG on trophoblast invasion was found to be mediated through extracellular matrix remodeling by facilitating the activity of MMP2 and MMP9 [13], [18], [44]. Both NSC 87877 are collagenases that degrade extracellular matrix. In canines, this has not yet been investi

• endothelin receptor antagonists There is sufficient evidence

  2021-10-19

  

  There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH endothelin receptor antagonists and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter r

• Although side effects as paresthesia

  2021-10-19

  

  Although side effects as paresthesia due to the application of β-alanine are known, a study in 2006 pointed out that there are no clinical (biochemical or hematological) changes after a long-term supplementation with β-alanine. In 2015, the International Society of Sports Nutrition rejected any argu

• After brain injury adenosine levels rapidly increase in the

  2021-10-19

  

  After brain injury, adenosine levels rapidly increase in the brain [9,10]. As shown in our previous studies, the increased adenosine concentration acts on adenosine A2A receptors (A2ARs), increasing post-traumatic glutamate levels in the brain and exacerbating the severity of injuries [11,12]. Accor

15133 records 586/1009 page Previous Next First page 上5页 586587588589590 下5页 Last page